You need to create 2 files in public_html of website where suPHP is enabled. A .htaccess specifying path to php.ini configuration and a php.ini with directives.
You can change php settings and load extensions from a central php.ini for all site folders.
Example for account “account-name”. Make sure you update that in .htaccess content:
.htaccess
suPHP_ConfigPath /home/[account-name]/public_html
php.ini
register_globals = Off
extension=pdo.so
extension=pdo_sqlite.so
extension=sqlite.so
extension=pdo_mysql.so
extension=geoip.so